Objective: The aim of this investigation was the estimation of diagnostic accuracy and to carry out comparative analysis of data received by Doppler ultrasonography (DUS), elastography and FibroTest for evaluation of liver fibrosis stage for patients with CHC and CHB.
Methods: 200 patients, age 35.6±10.9 years were investigated clinically at Vasilenko Clinic. Hospitalized patients with diagnosis of chronic hepatitis - 75% (HCVRNA +) and 25% (HBVDNA +) were divided in three groups, each investigated using one of three methods: DUS, elastography and FibroTest (100, 50 and 50 patients, respectively). Splenic artery pulsatility index (SAPI) and mean velocity of portal vein blood flow (MVPV) were determined by Doppler ultrasonography. The results of non-invasive methods were compared to data of fibrosis according to METAVIR. Taking into account the stage of fibrosis, all patients were separated into groups (F0-F1) and (F2-F4). The statistical data was processed in SPSS 16.0.
Results: The comparative analysis of results has revealed the informativity of the studied methods: Elastography (AUROC - 0.888; 95%-CI - 0.815-0.960; p <0.001), FibroTest (AUROC - 0.884; 95%-CI - 0.824-0.944; p <0.001), DUS SAPI (AUROC - 0.843; 95%-CI - 0.755-0.930; p <0.001), DUS MVPV (AUROC - 0.695; 95%-CI - 0.591-0.820; p =0.001).
Conclusions: Data of DUS, elastography and FibroTest is highly reliable, informative and allows to carry out non-invasive diagnostics of severe (F2-F4) liver fibrosis for patients with CHC and CHB. High level of accuracy comparing to the traditional needle liver biopsy allows recommending the investigated methods in clinical practice as independent screening methods.