Objective: Evaluation of information value and comparative analysis of diagnostic accuracy of Doppler ultrasonography, elastography and FibroTest in non-invasive diagnostics of liver cirrhosis for patients with CHC and CHB.
Methods: Overall 200 patients, mean age 35.6±10.9 years were investigated. Patients were represented by three groups, each of them has been studied using one of three methods: Doppler ultrasonography, elastography and FibroTest (100, 50 and 50 patients, respectively). Patients were hospitalized at Vasilenko clinic with diagnosis of chronic hepatitis - 75 % (HCVRNA +) and 25 % (HBVDNA +). The obtained results were compared to the data according to METAVIR. Splenic artery pulsatility index (SAPI) and mean velocity of portal vein blood flow (MVPV) were determined by Doppler ultrasonography. Then patients were divided in two groups depending on the stage of liver fibrosis: first — with F0-F3 fibrosis stage and second — with liver cirrhosis (F4). Statistical processing of results was performed by SPSS 16.0.
Results: The comparative analysis of results has revealed the informativity of the studied methods: Elastography (AUROC - 0.963; 95%-CI: 0.929-0.997; p<0.001), FibroTest (AUROC - 0.950; 95%-CI: 0.894-1.005; p<0.001), DUS SAPI (AUROC - 0.912; 95%-CI: 0.785-0.954; p<0.001), DUS MVPV (AUROC - 0.803; 95%-CI: 0.690-0.946; p<0.001).
Conclusions: DUS, elastography and FibroTest scores are characterized by high informative value and reliably represent development of liver cirrhosis in CHC and CHB patients. High diagnostic accuracy of these methods allows recommending them as screening diagnostics tests to reveal patients with F4 liver fibrosis who have no clinical signs of cirrhosis.