Clinical Study of Solid Pancreatic Focal Lesions with Contrast-Enhanced Ultrasound

  • Professor Xiaoyan Xie, Department of Ultrasonic,the First Affiliated Hospital, Sun Yat-Sen University, China
  • Dr Luyao Zhou, Department of Ultrasonic,the First Affiliated Hospital, Sun Yat-Sen University, China
  • Professor Huixiong Xu, Department of Ultrasonic,the First Affiliated Hospital, Sun Yat-Sen University, China
  • Dr Zuofeng Xu, Department of Ultrasonic,the First Affiliated Hospital, Sun Yat-Sen University, China
  • Profssor Xiaohua Xie, Department of Ultrasonic,the First Affiliated Hospital, Sun Yat-Sen University, China
  • Profssor Mingde Lu, Department of Hepatobilialy Surgery,the First Affiliated Hospital, Sun Yat-Sen University, China

    • Objective: To investigate the value of enhancement patterns of contrast-enhanced ultrasound in differential diagnosis of solid focal lesions of pancreas (s-FLPs).
    Methods: By analyze the characterizations in different phases of 89 solid focal lesions of pancreas with final diagnosis which were examined with ultrasound contrast agent SonoVue combined with low mechanical index contrast-enhanced ultrasound technique retrospectively, we investigate the value of differential diagnosis in contrast-enhanced ultrasound.
    Results: There were no statistically significant difference in the surrounding pancreas parenchyma enhancement time, the lesion enhancement time and the peak enhancement time between different group of solid focal lesions(P>0.05). There was a statistically significant difference in beginning to peak enhancement time between pancreatic carcinoma group and no pancreatic carcinoma group (P=0.006). Be used the enhancement model as a diagnosis index to differentiate pancreatic carcinoma and tumor –like panceatitis, the sensitivity, sensitivity,accuracy were 89.7%, 95.2%, 91.1%;81.3%, 100%, 96.6% respectively. Combination of variant index showed enhancement model and enhancement speed had best diagnosis result, but no change in Youden index.
    Conclusion: Different solid focal lesions of pancreas show different enhancements display in contrast-enhanced ultrasound. But the enhancement model and enhancement speed were the most useful diagnosis index.