The Diagnostic Efficacy of Contrast Enhanced Ultrasonography with Sonazoid in Metastatic Liver Tumor from Colorectal Cancer. – Comparison with PET-CT

  • Dr Hironori Ochi, Eulji General Hospital, Japan
  • Dr Atsushi Hiraoka, Ehime Prefectural Central Hospital, Japan
  • Dr Kojiro Michitaka, Ehime Prefectural Central Hospital, Japan
  • Dr Takahide Uehara, Ehime Prefectural Central Hospital, Japan
  • Dr Satoshi Hidaka, Ehime Prefectural Central Hospital, Japan
  • Dr Tomoyuki Ninomiya, Ehime Prefectural Central Hospital, Japan
  • Dr Yasunao Miyamoto, Ehime Prefectural Central Hospital, Japan
  • Dr Hiromasa Nakahara, Ehime Prefectural Central Hospital, Japan

    • Aim: Contrast enhanced ultrasonography (CEUS) with Perflubutane (Sonazoid®, Daiichisankyo Co,Ltd) has reported to be useful for diagnosing hepatocellular carcinoma, however, there is a paucity of information regarding diagnostic efficacy of CEUS for metastatic liver tumor. We analyzed the diagnostic efficacy of Sonazoid® for metastasis from colorectal cancer, by comparing the results with those of 18-fluoro-2-deoxyglucose positron emission tomography (PET) -computed tomography (CT).
    Method: Subjects were 36 patients colorectal cancer. PET-CT and CEUS were performed in all patients within one month. After injecting Sonazoid® (0.5ml), livers were scanned by CEUS in two phases: arterial and liver-specific (Kupffer) phase using EUB7500 (Hitachi). The results of PET-CT were not showed to operator of CEUS. In the cases with different results between CEUS and PET-CT, dynamic CT and/or magnetic resonance imaging were used for assistant diagnostic methods.
    Results: Nodules in liver were found in 16 patients by PET-CT, whereas in 18 patients by CEUS. If the results with PET-CT was settled as gold standard, the sensitivity and specificity with CEUS was 93.7% and 90.0% respectively.Multiple nodules were found by PET-CT in 10 patients and the number of the detected nodules found by CEUS was the same in 9 patients. Nodules less than 1 cm in diameter were detectable by PET-CT as well as CEUS in a considerable number of patients.
    Conclusion: Sonazoid® was thought to be effective in screening for metastatic tumors from colorectal cancer.