Relationship Between Longitudinal and Radial Contractility by Velocity Vector Imaging in Rabbits with Early Adriamycin-induced Myocardial Damage

  • An-hua Li, Department of Ultrasound, National Key Laboratory of Oncology in southern China, Cancer Center, Sun Yat-sen University,, China
  • Long-zhong Liu, Department of Ultrasound, National Key Laboratory of Oncology in southern China, Cancer Center, Sun Yat-sen University,, China
  • Wei Zhen, Department of Ultrasound, National Key Laboratory of Oncology in southern China, Cancer Center, Sun Yat-sen University,, China
  • Xiao-qing Pei, Department of Ultrasound, National Key Laboratory of Oncology in southern China, Cancer Center, Sun Yat-sen University,, China

    • Objective: To evaluate the experimental value with Velocity Vector Imaging (VVI) in early assessment of left ventricular longitudinal and radial systolic function in rabbits with adriamycin-induced myocardial damage.
    Method: 41 rabbits were divided into four groups (9,10,10 and 12 rabbits in groups A,B,C and D respectively).Adrimycin was administrated in 2mg/kg once week from 2, 4, 8 weeks at Group B, C and D. 9 rabbits in group A was administrated saline. After 2 weeks of completing injection, Routinal echocardiography and VVI parameters (velocity, strain, strain rate) were measured.Histological examination were completed after rabbits sacrificed.
    Results: In group C,only longitudinal strain from serveral segments were significantly lower than that in group A (P O.O5).In group D, longitudinal velocity, strain and strain rate from all segments were significantly lower that those in group A (P O.O5).The pathological examination demonstrated that the damage severity was progressively increased from groups B to C to D.
    Conclusions: The different VVI between longitudinal and radial contractility was helpful for our recognition of early adriamycin-induced myocardial pathological damage by imaging method.
    Keywords: Velocity Vector Imaging, Adriamycin, Left ventricular, Longitudinal, Radial