Objective: To study the changes of fetal hemodynamic in ovine fetus to systemic inflammatory response syndrome(SIRS)and evaluate the relationship between hemodynamic and TNF-α and IL-6.
Methods: 17 late-gestation fetal sheep underwent cordocentesis or amniocentesis under ultrasound guidance. Echocardiography were performed in different time. Fetal blood samples were collected to measure for TNF-α and IL-6.
Results: After LPS administration, the fetal plasma TNF-α ,IL-6 level and fetal UmA PI,RA PI,DV PI,MCA PI,LV, RV EF,LV, RV Tei indices,TV, MV E/A ratio significantly changed with time( P<0.05), and still significantly increased as compared with the control animals ( P<0.05).There were significantly correlation between fetal hemodynamic values and TNF-α, IL-6(P<0.01).
Conclusions: DV PI ,Tei index and TNF-α,IL-6 level exhibits the strongest relation in the peripheral vessels or in the cardiac function values,respectively. Therefore, DV PI and Tei index might be easy and useful quantitative parameters for assessing fetal SIRS.