We are focusing on the use of ultrasound in diagnosis NHL for local standing and response monitoring. The purpose of this study was to describe an ultrasound semiotics of NHL with damage to the female genital tract. Twenty three cases of NHL were identified. Of these, there were 11 patients NHL of breast, 9 lymphoma of uterus, one case lymphoma of cervix uterine and two lymphoma of vagina. Of the 23 pts, 10 were in advanced stage and 4 pts with relapsed of NHL. Characteristics of patients: age 27-75 years; B symptoms were 9 pts; clinical symptoms were nonspecific and mimic other more common gynecologic malignancies; the different morphological variants included diffuse and follicular B-cell – 21 pts, one case of peripheral T-cell NHL with involvement of the uterus, breast and skin, one case of Burkitt's lymphoma. The lymphoma of breast was presented as a round or oval tumors with abnormal increased echogenicity, sizes from 1.7 cm to 7.8 cm into the breast tissue. 77.8% patients with primary uterus NHL were aged 40-50 years. There were an increase of the uterine size and the asymmetry of walls due to nodes from 2 to 10 cm in diameter. Thier homogeneous structures didn’t depend on the size. We suggested the presence of lymphoma in 55.5% of cases. Doppler imaging showed a good peripheral vascularity into the each hypoechoic mass of NHL. The modern high-tech ultrasound for NHL in no way inferior to the diagnostic possibilities of other anatomical topographic ray diagnostic techniques.